A monoclonal antibody distinguishes between two IgM heavy chain isotypes in Atlantic salmon and brown trout: protein characterization, 3D modeling and epitope mapping.

Abstract

Atlantic salmon (Salmo salar) and brown trout (Salmo trutta) possess two distinct subpopulations of IgM which can be separated by anion exchange chromatography. Accordingly, there are two isotypic μ genes in these species, related to ancestral tetraploidy. In the present work it was verified by mass spectrometry that IgM of peak 1 (subpopulation 1) have… (More)
DOI: 10.1016/j.molimm.2011.05.005

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@article{Kamil2011AMA, title={A monoclonal antibody distinguishes between two IgM heavy chain isotypes in Atlantic salmon and brown trout: protein characterization, 3D modeling and epitope mapping.}, author={Atif Kamil and Knut Falk and Animesh Sharma and Arnt Johan Raae and Frode S. Berven and Erling Olaf Koppang and Ivar Hordvik}, journal={Molecular immunology}, year={2011}, volume={48 15-16}, pages={1859-67} }