A monoclonal antibody defines a novel HIV type 1 Tat domain involved in trans-cellular trans-activation.

@article{Valvatne1996AMA,
  title={A monoclonal antibody defines a novel HIV type 1 Tat domain involved in trans-cellular trans-activation.},
  author={H{\aa}vard Valvatne and Anne Marie Szilvay and Dag E Helland},
  journal={AIDS research and human retroviruses},
  year={1996},
  volume={12 7},
  pages={611-9}
}
In the present study, a CAT assay, a beta-galactosidase assay, and immunofluorescence analysis have been used to study the cellular uptake of the HIV-1 Tat protein. An anti-Tat MAb binding to an epitope comprising both the basic domain and the RGD sequence inhibits trans-activation by exogenous Tat. Two different full-length recombinant Tat proteins were used in these studies. The inhibitory MAb, however, recognized only one of the recombinant Tat proteins. Immunofluorescence analysis… CONTINUE READING

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