• Chemistry, Medicine
  • Published in
    The Journal of biological…
    1989

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.

@article{Taub1989AMA,
  title={A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.},
  author={Rebecca Taub and Robert J. Gould and Victor M. Garsky and Terrence M. Ciccarone and James A Hoxie and Paul A. Friedman and Sanford J Shattil},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 1},
  pages={
          259-65
        }
}
The binding of fibrinogen to its platelet receptor, the glycoprotein IIb-IIIa complex, is mediated, in part, by an Arg-Gly-Asp (RGD) sequence within the fibrinogen A alpha chain. PAC1 is an IgM-kappa murine monoclonal antibody that binds to the platelet fibrinogen receptor, and its binding is inhibited by both fibrinogen and RGD-containing peptides. To identify the regions of PAC1 that interact with the fibrinogen receptor, we determined the mRNA sequences of PAC1 immunoglobulin heavy and light… CONTINUE READING

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