A monoclonal antibody against the immunodominant epitope of the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta 1-adrenergic receptor.

@article{Mahler2001AMA,
  title={A monoclonal antibody against the immunodominant epitope of the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta 1-adrenergic receptor.},
  author={Evelyn Mahler and Pilar Sepulveda and O. de Jeannequin and P Li{\'e}geard and P. Gounon and Gerd Wallukat and Pierre Eftekhari and Mariano Jorge Levin and Johan Hoebeke and Mireille Hontebeyrie},
  journal={European journal of immunology},
  year={2001},
  volume={31 7},
  pages={2210-6}
}
Monoclonal antibodies were raised against a recombinant ribosomal P2beta protein of Trypanosoma cruzi. One of these reacted with the C terminus of this protein (peptide R13, EEEDDDMGFGLFD) and epitope mapping confirmed that this epitope was the same as the one defined by the serum of immunized mice, and similar to the previously described chronic Chagas' heart disease (cChHD) anti-P epitope. Western blotting showed that the monoclonal antibody recognized the parasite ribosomal P proteins, as… CONTINUE READING

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