A monoclonal antibody against the catalytic domain of PTP1B.

  title={A monoclonal antibody against the catalytic domain of PTP1B.},
  author={Fanwei Zeng and Erru Ni and Shengyu Wang and Sha Lv and Chang Qing Cao and Haipeng Zhang and Haiyan Lv and Xiaoli Chen and Jianghua Yan and Fanghong Luo},
  volume={31 3},
Protein tyrosine phosphatase 1B (PTP1B), a member of the protein tyrosine phosphatase (PTP) family, plays a crucial role in metabolic signaling, with insulin and leptin signaling being well studied. New evidence indicates that PTP1B is also involved in cancer. In the present study, we report on the establishment of a monoclonal antibody specific for catalytic domain of PTP1B (PTP1Bc) generated through the hybridoma method. The monoclonal antibody is measured to have a titer of 4.1×10(6) against… CONTINUE READING

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