A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains.

@article{Brown1983AMA,
  title={A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains.},
  author={A I Brown and Ten E N Feizi and Hock Chye Gooi and Michael J. Embleton and Jean K. Picard and Robert W. Baldwin},
  journal={Bioscience reports},
  year={1983},
  volume={3 2},
  pages={163-70}
}
A monoclonal antibody C14/1/46/10 showing preferential binding to membranes of human colorectal carcinomas over normal colon mucosae was obtained by immunization of mice with extra-nuclear membranes of a human colonic adenoma. Binding and inhibition of binding assays using blood cells or glycoproteins with known blood-group activities indicated that the antibody recognizes a carbohydrate antigen co-existing with the blood-group-H determinant: Fuc alpha 1 leads to 2 Gal. Inhibition assays with… CONTINUE READING

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