A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.

@article{Lenter1993AMA,
  title={A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.},
  author={M C Lenter and Holger Uhlig and Alf Hamann and Paul Jenoe and Beat Albert Imhof and Dietmar Vestweber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 19},
  pages={9051-5}
}
We have generated a monoclonal antibody (mAb), 9EG7, against mouse endothelial cells that blocks adhesion of lymphocytes to endothelial cells. Sequencing of four tryptic peptides of the purified antigen revealed its identity with the integrin chain beta 1. The only beta 1 integrin that is known to mediate cell-cell adhesion is alpha 4 beta 1 (VLA-4). This is not the integrin that is functionally defined by the mAb 9EG7 on endothelial cells. First, alpha 4 is not present on the analyzed… CONTINUE READING