A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme.

@article{Reyes1997AMA,
  title={A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme.},
  author={Ang{\'e}lica Reyes and Daniel Roberto Perez and Alejandra Moreno {\'A}lvarez and Jorge Garrido and Mary K. Gentry and Bhupendra P. Doctor and Nibaldo C Inestrosa},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={232 3},
  pages={652-5}
}
A monoclonal antibody (mAb) 25B1 directed against fetal bovine-serum acetylcholinesterase (FBS AChE) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (A beta) into Alzheimerś fibrils. This mAb binds to the peripheral anionic site of the enzyme and allosterically inhibits catalytic activity of FBS… CONTINUE READING