A molluscan peptide alpha-amidating enzyme precursor that generates five distinct enzymes.

@article{Spijker1999AMP,
  title={A molluscan peptide alpha-amidating enzyme precursor that generates five distinct enzymes.},
  author={Sabine Spijker and August B. Smit and Betty A Eipper and Ajamaluddin Malik and Richard E Mains and Wijnand P. M. Geraerts},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1999},
  volume={13 6},
  pages={
          735-48
        }
}
Mechanisms underlying the specificity and efficiency of enzymes, which modify peptide messengers, especially with the variable requirements of synthesis in the neuronal secretory pathway, are poorly understood. Here, we examine the process of peptide alpha-amidation in individually identifiable Lymnaea neurons that synthesize multiple proproteins, yielding complex mixtures of structurally diverse peptide substrates. The alpha-amidation of these peptide substrates is efficiently controlled by a… CONTINUE READING

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