A molecular view on the interaction of the trojan peptide penetratin with the polar interface of lipid bilayers.

@article{Binder2004AMV,
  title={A molecular view on the interaction of the trojan peptide penetratin with the polar interface of lipid bilayers.},
  author={Hans Binder and G{\"o}ran Lindblom},
  journal={Biophysical journal},
  year={2004},
  volume={87 1},
  pages={
          332-43
        }
}
Penetratin belongs to the family of Trojan peptides that effectively enter cells and therefore can be used as cargoes for agents that are unable to penetrate the cell membrane. We applied polarized infrared spectroscopy in combination with the attenuated total reflection technique to extract information before penetratin binding to lipid membranes with molecular resolution. The amide I band of penetratin in the presence of zwitterionic dimyristoylphosphatidylcholine and of anionic lipid… CONTINUE READING

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Breaching barriers—protein transduction and similar methods are promising techniques for delivering a wide variety of drugs directly into cell

  • C. M. Henry, C. E. Washington.
  • Chem. Eng. News. 81:35–43.
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