A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis

  title={A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis},
  author={Michel Becuwe and Neide Vieira and D. Contreras Lara and J{\'e}ssica A. Gomes-Rezende and Carina Soares-Cunha and Margarida Casal and Rosine Haguenauer-Tsapis and Olivier Vincent and Sandra Paiva and S{\'e}bastien L{\'e}on},
  booktitle={The Journal of cell biology},
Endocytosis regulates the plasma membrane protein landscape in response to environmental cues. In yeast, the endocytosis of transporters depends on their ubiquitylation by the Nedd4-like ubiquitin ligase Rsp5, but how extracellular signals trigger this ubiquitylation is unknown. Various carbon source transporters are known to be ubiquitylated and endocytosed when glucose-starved cells are exposed to glucose. We show that this required the conserved arrestin-related protein Rod1/Art4, which was… CONTINUE READING
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Membrane trafficking of yeast transporters : mechanisms and physiological control of downregulation

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Protein kinase C - dependent ubiquitination and clathrin - mediated endocytosis of the cationic amino acid transporter CAT - 1

  • J. Bender-Sigel, T. Sorkina, E. I. Closs, A. Sorkin
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