A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma.

@article{Teh2011AMS,
  title={A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma.},
  author={Muy-Teck Teh and Eric K. Parkinson and Johanna Thurlow and Feng Liu and Farida Fortune and H. Wan},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2011},
  volume={40 1},
  pages={67-76}
}
Desmosomes, the intercellular junctions that confer strong adhesion between epithelial cells, are frequently altered in malignancy. However, a comprehensive analysis of these structures has not been carried out in oral neoplasia. Oral squamous cell carcinomas (SCCs) and pre-malignant dysplasia can be sub-classified according to their in vitro replicative lifespan, where the immortal dysplasia (ID) and carcinoma (IC) subsets have p16(ink4a) and p53 dysfunction, telomerase deregulation and… CONTINUE READING