A molecular signature of metastasis in primary solid tumors

@article{Ramaswamy2003AMS,
  title={A molecular signature of metastasis in primary solid tumors},
  author={Sridhar Ramaswamy and Kenneth N. Ross and Eric S. Lander and Todd R. Golub},
  journal={Nature Genetics},
  year={2003},
  volume={33},
  pages={49-54}
}
Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To explore the molecular differences between human primary tumors and metastases, we compared the gene-expression profiles of adenocarcinoma metastases of multiple tumor types to unmatched primary adenocarcinomas. We found a gene-expression signature that distinguished primary from metastatic adenocarcinomas. More notably, we found that a subset of primary tumors… 
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