A molecular signature of metastasis in primary solid tumors

@article{Ramaswamy2003AMS,
  title={A molecular signature of metastasis in primary solid tumors},
  author={S. Ramaswamy and K. Ross and E. Lander and T. Golub},
  journal={Nature Genetics},
  year={2003},
  volume={33},
  pages={49-54}
}
Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To explore the molecular differences between human primary tumors and metastases, we compared the gene-expression profiles of adenocarcinoma metastases of multiple tumor types to unmatched primary adenocarcinomas. We found a gene-expression signature that distinguished primary from metastatic adenocarcinomas. More notably, we found that a subset of primary tumors… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Gene expression profiling predicts clinical outcome of breast cancer
Gene expression correlates of clinical prostate cancer behavior.
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Molecular portraits of human breast tumours
Multiclass cancer diagnosis using tumor gene expression signatures
  • S. Ramaswamy, P. Tamayo, +12 authors T. Golub
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Genomic analysis of metastasis reveals an essential role for RhoC
Prediction of central nervous system embryonal tumour outcome based on gene expression
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.
  • L. Brown, A. Guidi, +5 authors H. Dvorak
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1999
Expression of pituitary-tumour transforming gene in colorectal tumours
Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer.
...
1
2
3
...