A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells

@article{Billaud2015AMS,
  title={A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells},
  author={Marie Billaud and Yu-Hsin Chiu and Alexander W. Lohman and Thibaud Parpaite and Joshua T. Butcher and Stephanie Mutchler and Leon J. DeLalio and Mykhaylo V Artamonov and Joanna K. Sandilos and Angela K. Best and Avril V. Somlyo and Roger J Thompson and Thu H Le and Kodi Ravichandran and Douglas A Bayliss and Brant E Isakson},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={ra17-ra17}
}
Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate) and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses. Using pharmacological approaches and mice conditionally lacking Panx1 in smooth muscle cells, we found that Panx1… CONTINUE READING
Tweets
This paper has been referenced on Twitter 12 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 87 references

Past and present

  • S. R. Bond, C. C. Naus, The pannexins
  • Front. Physiol. 5, 58
  • 2014
1 Excerpt

Ralevic , Purinergic signaling and blood vessels in health and disease

  • V.
  • Pharmacol . Rev .
  • 2014

Regulation of cellular communication by signaling microdomains in the blood vessel wall

  • A. W. Lohman Billaud, S. R. Johnstone, L. A. Biwer, S. Mutchler, B. E. Isakson
  • Pharmacol . Rev .
  • 2014