A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes.


The extreme 3'-ends of human telomeres consist of 150-250 nucleotides of single-stranded DNA sequence together with associated proteins. Small-molecule ligands can compete with these proteins and induce a conformational change in the DNA to a four-stranded quadruplex arrangement, which is also no longer a substrate for the telomerase enzyme. The modified… (More)
DOI: 10.1042/BST0370583

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