A molecular mechanism for the induction of neurofilament bundling by aluminum ions.

@article{Leterrier1992AMM,
  title={A molecular mechanism for the induction of neurofilament bundling by aluminum ions.},
  author={Jean François Leterrier and Dominique Langui and Alphonse Probst and J{\"u}rg Ulrich},
  journal={Journal of neurochemistry},
  year={1992},
  volume={58 6},
  pages={2060-70}
}
A1 induces neurofibrillary tangles in the perikaryon of neurons in vivo and in culture. The effect of A1 ions complexed with maltol, a plant-derived ligand of A1, on purified neurofilament preparations was studied in vitro. The binding of A1 to the arm-like projections of the high (H)- and medium (M)-molecular-weight neurofilament subunits causes a conformational change of the molecule (intrafilamentous reaction), characterized by an altered migration on sodium dodecyl sulfate-polyacrylamide… CONTINUE READING