A molecular mechanism for osmolyte-induced protein stability.

  title={A molecular mechanism for osmolyte-induced protein stability.},
  author={Timothy O Street and David Wayne Bolen and George D. Rose},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 38},
Osmolytes are small organic compounds that affect protein stability and are ubiquitous in living systems. In the equilibrium protein folding reaction, unfolded (U) native (N), protecting osmolytes push the equilibrium toward N, whereas denaturing osmolytes push the equilibrium toward U. As yet, there is no universal molecular theory that can explain the mechanism by which osmolytes interact with the protein to affect protein stability. Here, we lay the groundwork for such a theory, starting… CONTINUE READING
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