A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

@article{Ariey2014AMM,
  title={A molecular marker of artemisinin-resistant Plasmodium falciparum malaria},
  author={Fr{\'e}d{\'e}ric Ariey and Beno{\^i}t Witkowski and Chanaki Amaratunga and Johann Beghain and Anne-Claire Langlois and Nimol Khim and Sungjune Kim and Valentine Duru and Christiane Bouchier and Laurence J. C. Ma and Pharath Lim and Rithea Leang and Socheat Duong and Sokunthea Sreng and Seila Suon and Char Meng Chuor and Denis Mey Bout and Sandie M{\'e}nard and William Oscar Rogers and Blaise Genton and Thierry Fandeur and Olivo Miotto and Robert D. Newman and Jacques Le Bras and Antoine Jean Berry and Jean-Christophe Barale and Rick M. Fairhurst and Françoise Beno{\^i}t-Vical and Odile Mercereau-Puijalon and DANIELLE. Menard},
  journal={Nature},
  year={2014},
  volume={505},
  pages={50-55}
}
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’) with artemisinin resistance in vitro and in vivo… CONTINUE READING
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