A molecular information ratchet

@article{Serreli2007AMI,
  title={A molecular information ratchet},
  author={Viviana Serreli and Chin‐Fa Lee and Euan R Kay and David A. Leigh},
  journal={Nature},
  year={2007},
  volume={445},
  pages={523-527}
}
Motor proteins and other biological machines are highly efficient at converting energy into directed motion and driving chemical systems away from thermodynamic equilibrium. But even though these biological structures have inspired the design of many molecules that mimic aspects of their behaviour, artificial nanomachine systems operate almost exclusively by moving towards thermodynamic equilibrium, not away from it. Here we show that information about the location of a macrocycle in a rotaxane… 
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References

SHOWING 1-10 OF 41 REFERENCES
Beyond switches: ratcheting a particle energetically uphill with a compartmentalized molecular machine.
TLDR
It is suggested that considering the relationship between the parts of a molecular machine and a substrate in terms of "statistical balance" and "linkage" could be useful in the design of more complex systems and in helping to understand the role of individual amino acids and peptide fragments during the directional transport of substrates by biological pumps and motors.
Unidirectional rotary motion in a molecular system
TLDR
A molecule is described that uses chemical energy to activate and bias a thermally induced isomerization reaction, and thereby achieve unidirectional intramolecular rotary motion.
Macroscopic transport by synthetic molecular machines
TLDR
A wholly synthetic molecular system that converts an external energy source (light) into biased brownian motion to transport a macroscopic cargo and do measurable work is described.
Unidirectional rotation in a mechanically interlocked molecular rotor
TLDR
It is shown that sequential and unidirectional rotation can also be induced in mechanically interlocked assemblies comprised of one or two small rings moving around one larger ring.
A Reversible Synthetic Rotary Molecular Motor
TLDR
The minimalist nature of the [2]catenane flashing ratchet design permits certain mechanistic comparisons with the Smoluchowski-Feynman ratchet and pawl.
Fluctuation driven transport and models of molecular motors and pumps
TLDR
The thermodynamics and kinetics for the operation of microscopic ratchet motors under conditions relevant to biology are discussed, showing how energy provided by external fluctuations or a non-equilibrium chemical reaction can cause unidirectional motion or uphill pumping of a substance.
Light-driven monodirectional molecular rotor
Attempts to fabricate mechanical devices on the molecular level have yielded analogues of rotors, gears, switches, shuttles, turnstiles and ratchets. Molecular motors, however, have not yet been
Mechanical twisting of a guest by a photoresponsive host
TLDR
This design concept, which significantly extends the successful coupling of motion beyond the intramolecular level seen in synthetic allosteric receptors, might allow for the remote control of molecular events in larger interlocked molecular systems.
A Reversible, Unidirectional Molecular Rotary Motor Driven by Chemical Energy
With the long-term goal of producing nanometer-scale machines, we describe here the unidirectional rotary motion of a synthetic molecular structure fueled by chemical conversions. The basis of the
Energy transduction of isothermal ratchets: generic aspects and specific examples close to and far from equilibrium.
We study the energetics of isothermal ratchets which are driven by a chemical reaction between two states, and operate in contact with a single heat bath of constant temperature. We discuss generic
...
1
2
3
4
5
...