A molecular dynamics study of the response of lipid bilayers and monolayers to trehalose.

@article{Skibinsky2005AMD,
  title={A molecular dynamics study of the response of lipid bilayers and monolayers to trehalose.},
  author={Anna Skibinsky and Richard M. Venable and Richard W. Pastor},
  journal={Biophysical journal},
  year={2005},
  volume={89 6},
  pages={4111-21}
}
Surface tensions evaluated from molecular dynamics simulations of fully hydrated dipalmitoylphosphatidylcholine bilayers and monolayers at surface areas/lipid of 54, 64, and 80 A2 are uniformly lowered 4-8 dyn/cm upon addition of trehalose in a 1:2 trehalose/lipid ratio. Constant surface tension simulations of bilayers yield the complementary result: an increase in surface area consistent with the surface pressure-surface area (pi-A) isotherms. Hydrogen bonding by trehalose, replacement of… CONTINUE READING
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