A molecular dynamics study of slow base flipping in DNA using conformational flooding.

@article{Bouvier2007AMD,
  title={A molecular dynamics study of slow base flipping in DNA using conformational flooding.},
  author={Benjamin Bouvier and Helmut Grubm{\"u}ller},
  journal={Biophysical journal},
  year={2007},
  volume={93 3},
  pages={770-86}
}
Individual DNA bases are known to be able to flip out of the helical stack, providing enzymes with access to the genetic information otherwise hidden inside the helix. Consequently, base flipping is a necessary first step to many more complex biological processes such as DNA transcription or replication. Much remains unknown about this elementary step, despite a wealth of experimental and theoretical studies. From the theoretical point of view, the involved timescale of milliseconds or longer… CONTINUE READING
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DNA base flipping by a basepair-mimic nucleoside

  • S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, N. Sugimoto
  • Nucleic Acids Res
  • 2005
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