A molecular diagnostic approach able to detect the recurrent genetic prognostic factors typical of presenting myeloma

@inproceedings{Boyle2015AMD,
  title={A molecular diagnostic approach able to detect the recurrent genetic prognostic factors typical of presenting myeloma},
  author={Eileen Mary Boyle and Paula Zuzanna Proszek and Martin F Kaiser and Dil B Begum and Nasrin M Dahir and Suvi Savola and Christopher P Wardell and Xavier Leleu and Fiona M. Ross and Laura Chiecchio and Gordon Cook and Mark Trehane Drayson and Richard G Owen and John Ashcroft and Graham Hunter Jackson and James Anthony Child and Faith Elizabeth Davies and Brian A Walker and Gareth J Morgan},
  booktitle={Genes, chromosomes & cancer},
  year={2015}
}
Risk stratification in myeloma requires an accurate assessment of the presence of a range of molecular abnormalities including the differing IGH translocations and the recurrent copy number abnormalities that can impact clinical behavior. Currently, interphase fluorescence in situ hybridization is used to detect these abnormalities. High failure rates, slow turnaround, cost, and labor intensiveness make it difficult and expensive to use in routine clinical practice. Multiplex ligation-dependent… CONTINUE READING