A molecular code for splicing silencing: configurations of guanosine-rich motifs.

@article{Grabowski2004AMC,
  title={A molecular code for splicing silencing: configurations of guanosine-rich motifs.},
  author={Paula J. Grabowski},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt 6},
  pages={924-7}
}
Alternative pre-mRNA splicing is frequently used to expand the protein-coding capacity of genomes, and to regulate gene expression at the post-transcriptional level. It is a significant challenge to decipher the molecular language of tissue-specific splicing because the inherent flexibility of these mechanisms is specified by numerous short sequence motifs distributed in introns and exons. In the present study, we employ the glutamate NMDA (N-methyl-D-aspartate) R1 receptor (GRIN1) transcript… CONTINUE READING

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Nature (London) 418

  • A. N. Ladd, T. A. Cooper
  • Genome Biol
  • 2002

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