A molecular chaperone inducer protects neurons from ER stress

  title={A molecular chaperone inducer protects neurons from ER stress},
  author={Takashi Kudo and Soshi Kanemoto and Hideaki Hara and Nobutaka Morimoto and T. Morihara and Rumi Kimura and Takeshi Tabira and Kazunori Imaizumi and Michio Takeda},
  journal={Cell Death and Differentiation},
The endoplasmic reticulum (ER) stress response is a defense system for dealing with the accumulation of unfolded proteins in the ER lumen. Recent reports have shown that ER stress is involved in the pathology of some neurodegenerative diseases and cerebral ischemia. In a screen for compounds that induce the ER-mediated chaperone BiP (immunoglobulin heavy-chain binding protein)/GRP78 (78 kDa glucose-regulated protein), we identified BiP inducer X (BIX). BIX preferentially induced BiP with slight… CONTINUE READING
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Transient cerebral ischemia activates processing of xbp1 messenger RNA indicative of endoplasmic reticulum stress.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2003
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