A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

@article{Cohen2015AMC,
  title={A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers},
  author={Samuel I. A. Cohen and Paolo Arosio and Jenny Presto and Firoz Roshan Kurudenkandy and Henrik Biverst{\aa}l and Lisa Dolfe and Christopher J.R. Dunning and Xiaoting Yang and Birgitta Frohm and Michele Vendruscolo and Jan E Johansson and Christopher M. Dobson and Andr{\'e} Fisahn and Tuomas P. J. Knowles and Sara Linse},
  journal={Nature Structural &Molecular Biology},
  year={2015},
  volume={22},
  pages={207-213}
}
Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces effectively catalyze the formation of neurotoxic oligomers. Here we show that a molecular chaperone, a human Brichos domain, can specifically inhibit this catalytic cycle and limit human Aβ42 toxicity. We demonstrate in vitro that Brichos achieves this… CONTINUE READING