A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.

@article{Liu2014AMB,
  title={A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.},
  author={Yu Chih Liu and Zhenjun Chen and Michelle A. Neller and John J. Miles and Anthony W. Purcell and James McCluskey and Scott R. Burrows and Jamie Rossjohn and Stephanie Gras},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 24},
  pages={16688-98}
}
Mutations within T cell epitopes represent a common mechanism of viral escape from the host protective immune response. The diverse T cell repertoire and the extensive human leukocyte antigen (HLA) polymorphism across populations is the evolutionary response to viral mutation. However, the molecular basis underpinning the interplay between HLA polymorphism, the T cell repertoire, and viral escape is unclear. Here we investigate the T cell response to a HLA-B*35:01- and HLA-B*35:08-restricted… CONTINUE READING

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NUMBER 24 JOURNAL OF BIOLOGICAL CHEMISTRY 16697 at U C SF L irary & C K M on M arch 1, 2015 hp://w w w .jb.org/ D

  • D B., R. Holdsworth, +5 authors J. McCluskey
  • HLA Polymorphism and Viral Escape JUNE
  • 2014
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