A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.

@article{Wun2011AMB,
  title={A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.},
  author={Kwok S. Wun and Garth Cameron and Onisha Patel and Siew Siew Pang and Daniel G. Pellicci and Lucy C Sullivan and Santosh Keshipeddy and Mary Hoover Young and Adam P. Uldrich and Meena Singh Dilip Thakur and Stewart K. Richardson and Amy R Howell and Petr Illarionov and Andrew G. Brooks and Gurdyal S Besra and James McCluskey and Laurent Gapin and Steven A. Porcelli and Dale I Godfrey and Jamie Rossjohn},
  journal={Immunity},
  year={2011},
  volume={34 3},
  pages={327-39}
}
Natural killer T (NKT) cells respond to a variety of CD1d-restricted antigens (Ags), although the basis for Ag discrimination by the NKT cell receptor (TCR) is unclear. Here we have described NKT TCR fine specificity against several closely related Ags, termed altered glycolipid ligands (AGLs), which differentially stimulate NKT cells. The structures of five ternary complexes all revealed similar docking. Acyl chain modifications did not affect the interaction, but reduced NKT cell… CONTINUE READING

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