A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

@article{Ladell2013AMB,
  title={A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.},
  author={Kristin Ladell and Masao Hashimoto and Maria Candela Iglesias and Pascal G. Wilmann and James E. McLaren and Stephanie Gras and Takayuki Chikata and Nozomi Kuse and Sol{\`e}ne Fastenackels and Emma Gostick and John Stephen Bridgeman and Vanessa Venturi and Za{\"i}na A{\"i}t Arkoub and Henri Agut and David van Bockel and Jorge R. Almeida and Daniel C. Douek and Laurence Meyer and Alain Venet and Masafumi Takiguchi and Jamie Rossjohn and David A. Price and Victor Appay},
  journal={Immunity},
  year={2013},
  volume={38 3},
  pages={425-36}
}
The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1-specific CD8+ T cell responses directed against the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263-272) presented by human leukocyte antigen (HLA)-B∗2705. We found that cross-reactive CD8+ T cell clonotypes were mobilized to counter the rapid emergence of HIV-1 variants that can directly affect T… CONTINUE READING
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