A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

  title={A molecular basis for the Ia.2 and Ia.19 antigenic determinants.},
  author={D Landais and Hans Matthes and C. Benoist and Diane Mathis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 9},
The murine Ia antigens, heterodimeric glycoproteins on the surface of immunocompetent cells, restrict immune recognition by their influence on cell-cell interactions. Many serological specificities have been mapped to these molecules, and monoclonal antibodies directed against some of these determinants block antigen presentation to T lymphocytes. As a step toward a better understanding of Ia function, we sought to define the molecular basis of Ia.2 and Ia.19, specificities found on the A alpha… CONTINUE READING

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