A molecular basis for nonsecretory myeloma.

  title={A molecular basis for nonsecretory myeloma.},
  author={Daniel Coriu and Kristal Weaver and Maria Schell and Manfred Eulitz and Charles L. Murphy and Deborah T. Weiss and Alan Solomon},
  volume={104 3},
The biosynthesis of aberrant immunoglobulin polypeptides by monoclonal plasma cells has been implicated in the pathogenesis of nonsecretory myeloma. Our studies of a patient with this disorder indeed have demonstrated the presence of abnormal kappa light chains that resulted from a frameshift mutation in nucleotides encoding the constant region of the molecule. As a consequence of a 2-base deletion in codon 187 and loss of the normal stop codon, this portion of the kappa chain was composed of… CONTINUE READING
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