A molecular basis for classic blond hair color in Europeans

  title={A molecular basis for classic blond hair color in Europeans},
  author={Catherine A. Guenther and Bosiljka Tasic and Liqun Luo and Mary A Bedell and David M. Kingsley},
  journal={Nature Genetics},
Hair color differences are among the most obvious examples of phenotypic variation in humans. Although genome-wide association studies (GWAS) have implicated multiple loci in human pigment variation, the causative base-pair changes are still largely unknown. Here we dissect a regulatory region of the KITLG gene (encoding KIT ligand) that is significantly associated with common blond hair color in northern Europeans. Functional tests demonstrate that the region contains a regulatory enhancer… CONTINUE READING
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Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans

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