A molecular basis for MHC class II--associated autoimmunity.

  title={A molecular basis for MHC class II--associated autoimmunity.},
  author={John A. Todd and Hans Acha-Orbea and John I. Bell and Nelson J Chao and Z Fronek and Chaim O. Jacob and M F McDermott and Animesh A. Sinha and Luika Timmerman and Lawrence Steinman},
  volume={240 4855},
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly… CONTINUE READING


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