A molecular NAND gate based on Watson-Crick base pairing.

@article{Baytekin2000AMN,
  title={A molecular NAND gate based on Watson-Crick base pairing.},
  author={H{\"u}seyin Taner Baytekin and Engin U Akkaya},
  journal={Organic letters},
  year={2000},
  volume={2 12},
  pages={
          1725-7
        }
}
  • Hüseyin Taner Baytekin, Engin U Akkaya
  • Published in Organic letters 2000
  • Chemistry, Medicine
  • [reaction: see text] A DNA-binding dye, 4',6-diamidino-2-phenylindole (DAPI) signals AT base pairing with a shift in the fluorescence emission spectrum. The signaling follows W-C base-pairing rules, and both dAMP and dTMP are required for the largest spectral shift. Thus, the dye with its two phosphate receptor sites functions as a molecular NAND gate accepting nucleotides as inputs. Moreover, when the observation wavelength is changed from 470 to 411.5 nm, the gate functions in TRANSFER logic. 

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