A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation

@article{Mobini2008AMA,
  title={A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation},
  author={Reza Mobini and Bengt A. Andersson and Jonas S Erjef{\"a}lt and Mirjana Hahn-Zoric and Michael A. Langston and Andy D. Perkins and Lars Cardell and Mikael Benson},
  journal={BMC Systems Biology},
  year={2008},
  volume={3},
  pages={19 - 19}
}
The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes. To test these… CONTINUE READING

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