A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.

@article{Tomlinson1996AML,
  title={A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.},
  author={Ian P. M. Tomlinson and Kenneth W. Neale and Ian C. Talbot and Allan D. Spigelman and Calvin B. Williams and Robin K. S. Phillips and W. F. Bodmer},
  journal={Journal of medical genetics},
  year={1996},
  volume={33 4},
  pages={
          268-73
        }
}
Mutations of the APC gene cause familial adenomatous polyposis (FAP) in humans and multiple intestinal neoplasia (Min) in laboratory mouse strains. A dominant modifying gene (Mom1), which partially suppresses the min phenotype, has been mapped to mouse chromosome 4. This region is syntenic with human chromosome 1p35-p36. The phospholipase A2 (Pla2s) locus is an excellent candidate for Mom1 and the equivalent human locus PLA2G2A is found on chromosome 1p35. It does not necessarily follow… CONTINUE READING

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