A modified toxicity probability interval method for dose-finding trials.

Abstract

BACKGROUND Building on earlier work, the toxicity probability interval (TPI) method, we present a modified TPI (mTPI) design that is calibration-free for phase I trials. PURPOSE Our goal is to improve the trial conduct and provide more effective designs while maintaining the simplicity of the original TPI design. METHODS Like the TPI method, the mTPI… (More)
DOI: 10.1177/1740774510382799

Topics

9 Figures and Tables

Cite this paper

@article{Ji2010AMT, title={A modified toxicity probability interval method for dose-finding trials.}, author={Yuan Ji and Ping Liu and Yisheng Li and B. Nebiyou Bekele}, journal={Clinical trials}, year={2010}, volume={7 6}, pages={653-63} }