A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant.

@article{Keating2012AMS,
  title={A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant.},
  author={Eleonora Keating and Yi Y Zuo and Seyed M. Tadayyon and Nils O. Petersen and Fred Possmayer and Ruud A. W. Veldhuizen},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1818 5},
  pages={1225-34}
}
The exact mechanism by which pulmonary surfactant films reach the very low surface tensions required to stabilize the alveoli at end expiration remains uncertain. We utilized the nanoscale sensitivity of atomic force microscopy (AFM) to examine phospholipid (PL) phase transition and multilayer formation for two Langmuir-Blodgett (LB) systems: a simple 3 PL surfactant-like mixture and the more complex bovine lipid extract surfactant (BLES). AFM height images demonstrated that both systems… CONTINUE READING
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