Linear system for quantiating hydrogen at a platinum electrode.
- E S HYMAN
- Circulation research
devices originally described by Clark and Bargeron1 in 1959 provide a simple, rapid and reproducible means of detecting and localizing intracardiac shunts. Their clinical application has been well documented in the past five years.25 This paper will describe a modification of the platinum electrode and its application and a modification of the method of hydrogen gas administration. The advantages of these modifications will be discussed. The potentiometric electrode: Clark and Bargeron1 applied the classic hydrogen reference electrode principle to the measurement of gaseous hydrogen concentration in the blood. Platinum electrodes coated with platinic chloride (platinized) were found to produce potentials up to 300 my with reference to a silver skin electrode upon exposure to blood containing hydrogen gas. These potentials exceed the normal cardiac potential and can be measured and recorded by conventional DC amplifiers and recording devices. This electrode provides a sensitive method for the recognition of both left-to-right and right-to-left intracardiac shunts. In the detection of left-to-right shunts, inspired hydrogen gas is dissolved in blood as it passes through the lung to enter the left heart. From there, part of the hydrogen-containing blood then enters the right heart through the defect