A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.

Abstract

A number of proteins have been rendered functionally oestrogen-dependent by fusion with the hormone-binding domain of the oestrogen receptor. There are, however, several significant disadvantages with such fusion proteins. First, their use in cells in vitro requires phenol red-free medium and laborious stripping of steroid hormones from serum in order to… (More)

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Cite this paper

@article{Littlewood1995AMO, title={A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.}, author={Trevor D. Littlewood and Darrell Hancock and Peter Danielian and M. G. Parker and Gerard I. Evan}, journal={Nucleic acids research}, year={1995}, volume={23 10}, pages={1686-90} }