A modified mouse air pouch model for evaluating the effects of compounds on granuloma induced cartilage degradation.

@article{Bottomley1988AMM,
  title={A modified mouse air pouch model for evaluating the effects of compounds on granuloma induced cartilage degradation.},
  author={K. M. K. Bottomley and Richard J. Griffiths and Trevor J. Rising and A. P. Steward},
  journal={British journal of pharmacology},
  year={1988},
  volume={93 3},
  pages={627-35}
}
1. Employing rat femoral head cartilage implanted in a 6 day old mouse air pouch, the effects of inflammatory stimuli (i.e. cotton pellets, carrageenan, zymosan) on the loss of proteoglycan and collagen and granuloma formation have been studied. 2. Wrapping of the cartilage in cotton resulted in granuloma formation with accelerated loss of proteoglycan and collagen over the 14 day implantation period. The amount of loss increased with increasing weight of cotton. 3. The effects of different… CONTINUE READING
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