A modified model for translocation events of processive nucleotide and repeat additions by the recombinant telomerase.

  • Ping Xie
  • Published 2010 in Biophysical chemistry


Telomerase is a unique reverse transcriptase that extends the single-stranded 3' overhangs of telomeres by copying a short template sequence within the integral RNA component of the enzyme. It shows processive nucleotide and repeat addition activities, which are realized via two types of movements: translocation of the DNA:RNA hybrid away from the active… (More)
DOI: 10.1016/j.bpc.2010.10.007