A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance.

@article{Parkkinen2006AMC,
  title={A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance.},
  author={Jaakko Parkkinen and A Rahola and Leni von Bonsdorff and Hannele T{\"o}l{\"o} and Ellinor T{\"o}rm{\"a}},
  journal={Vox sanguinis},
  year={2006},
  volume={90 2},
  pages={97-104}
}
BACKGROUND AND OBJECTIVES The increasing demand for intravenous immunoglobulin (IVIG) necessitates the development of improved plasma fractionation methods, providing higher immunoglobulin G (IgG) recovery. Here, we describe a new IVIG production process resulting in a high yield of IgG and effective reduction of physico-chemically resistant viruses. MATERIALS AND METHODS IgG was purified from Cohn fraction II+III by caprylic acid treatment, polyethylene glycol precipitation, anion-exchange… CONTINUE READING

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