A modified Folts model or the original Folts model to evaluate new antithrombotics?

Abstract

A modified Folts model or the original Folts model to evaluate new antithrombotics? I read with interest and some misgivings the report by Wu et al. 1 They used a modified Folts model in baboons receiving either a murine antihuman von Willebrand factor (VWF) monoclonal antibody (mAb) 82D6A3 (600␮g/kg, n ϭ 2, or 300␮g/kg, n ϭ 3) or a placebo (normal saline… (More)

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