A modification of jerne's theory of antibody production using the concept of clonal selection

  title={A modification of jerne's theory of antibody production using the concept of clonal selection},
  author={Frank Macfarlane Sir Burnet},
  journal={CA: A Cancer Journal for Clinicians},
  • F. Burnet
  • Published 1 March 1976
  • Medicine, Biology
  • CA: A Cancer Journal for Clinicians
There are three current theoretical inter pretations of antibody production which, following Talmage (1957), may be referredto as the directtemplate theoryinwhich theantigenservesasa template against which the specific pat tern of the antibody is synthesized, the indirect template theory which postu lates a secondary template incorporated intothegenetic-synthetic processesof the antibody producing cells (Burnet, 1956), and the natural selection theory in which the antigen acts essentially by… Expand
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  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1986
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  • Biology, Medicine
  • Journal of Biosciences
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  • Biology, Medicine
  • Reproductive biomedicine online
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  • Springer Seminars in Immunopathology
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The close association between the "classical" immune system and histocompatibility markers became increasingly obvious by the discovery of H-restricted phenomena in the actual immunization process as well as in cytotoxic T cell reactions. Expand
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