A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration.

  title={A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration.},
  author={Eva Aus{\'o} and Rosal{\'i}a Lavado-Autric and Estela Cuevas and Francisco Escobar del Rey and Gabriella Morreale de Escobar and P. Pere Berbel},
  volume={145 9},
Epidemiological studies and case reports show that even a relatively minor degree of maternal hypothyroxinemia during the first half of gestation is potentially dangerous for optimal fetal neurodevelopment. Our experimental approach was designed to result in a mild and transient period of maternal hypothyroxinemia at the beginning of corticogenesis. Normal rat dams received the goitrogen 2-mercapto-1-methyl-imidazole for only 3 d, from embryonic d 12 (E12) to E15. Maternal thyroid hormones… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 53 references

Iodine deficiency as a cause of brain damage.

Postgraduate medical journal • 2001
View 9 Excerpts
Highly Influenced

Thyroidal and extrathyroidal adaptation to graded degrees of iodine deficiency: an experimental rat model for the study of neurological iodine deficiency disorders (IDD)

G Morreale de Escobar, PE Pedraza, F Escobar del Rey, MJ Obregón
View 4 Excerpts
Highly Influenced

Thyroid hormones and brain development.

Vitamins and hormones • 2005
View 1 Excerpt

Maternal Thyroid and Fetal Neurodevelopment by on May 20, 2010 endo.endojournals.org

MR Celio, W Bayer, +3 authors AW Norman
Endocrinology, • 2004

Atten - tion deficit and hyperactivity disorders ( ADHD ) in the offspring of mothers exposed to iodine deficiency : a possible novel iodine deficiency disorder in developed countries

F Vermiglio, VP LoPresti, +8 authors F Trimarchi

Neuropsychological assessment in humans living in mild to moderate iodine deficiency

P Vitti, F Aghini-Lombardi, L Chiovato, G Ferretti, A Pinchera
In: de Vijlder J, Morreale de Escobar G, eds. The thyroid and the brain • 2003
View 1 Excerpt

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