A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration.

@article{Aus2004AMA,
  title={A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration.},
  author={Eva Aus{\'o} and Rosal{\'i}a Lavado-Autric and Estela Cuevas and Francisco Escobar del Rey and Gabriella Morreale de Escobar and P. Pere Berbel},
  journal={Endocrinology},
  year={2004},
  volume={145 9},
  pages={4037-47}
}
Epidemiological studies and case reports show that even a relatively minor degree of maternal hypothyroxinemia during the first half of gestation is potentially dangerous for optimal fetal neurodevelopment. Our experimental approach was designed to result in a mild and transient period of maternal hypothyroxinemia at the beginning of corticogenesis. Normal rat dams received the goitrogen 2-mercapto-1-methyl-imidazole for only 3 d, from embryonic d 12 (E12) to E15. Maternal thyroid hormones… CONTINUE READING

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