A model virus-cell system to study the persistence of African swine fever virus

@article{GilFernndez2005AMV,
  title={A model virus-cell system to study the persistence of African swine fever virus},
  author={Carmen Gil-Fern{\'a}ndez and Dolores Garc{\'i}a-Villal{\'o}n},
  journal={Archives of Virology},
  year={2005},
  volume={100},
  pages={161-169}
}
SummaryThe persistence of African swine fever virus (ASFV) on Vero cells was induced by using 5-iodo-2′-deoxyuridine (IDU). After the persistence was established, several cycles of decreasing virus production were observed with intervals in which no virus could be detected. These latency-like periods could last from 15 to 25 days. After three and a half months the cells appeared to be “cured” and no virus was detected during almost three years. These “cured” cells (Vero-L) were more resistant… 

Interferon cures cells lytically and persistently infected with African swine fever virus in vitro

The finding that continuous treatment with IFN-α cures Vero cells from lytic and persistent infections with ASF virus is found, suggesting a potential application of IFN for the treatment of animals carrying the virus.

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