A model to infer the pathogenic significance of CDH1 germline missense variants

Abstract

Germline mutations of the E-cadherin gene (CDH1) are involved in the tumorigenesis of hereditary diffuse gastric cancer (HDGC). Recent studies have highlighted the lifesaving potential of total prophylactic gastrectomy for CDH1 germline mutation carriers. In this regard, CDH1 germline mutations of the missense type represent a clinical burden in genetic… (More)
DOI: 10.1007/s00109-006-0091-z

Topics

7 Figures and Tables

Cite this paper

@article{Suriano2006AMT, title={A model to infer the pathogenic significance of CDH1 germline missense variants}, author={Gianpaolo Suriano and Susana Seixas and Jorge Rocha and Raquel Seruca}, journal={Journal of Molecular Medicine}, year={2006}, volume={84}, pages={1023-1031} }