A model to explain the osmotic pressure behavior of hemoglobin and serum albumin.

@article{Cameron1990AMT,
  title={A model to explain the osmotic pressure behavior of hemoglobin and serum albumin.},
  author={Ivan L. Cameron and Gary D. Fullerton},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1990},
  volume={68 5},
  pages={894-8}
}
Previously published osmotic pressure data on hemoglobin and bovine serum albumin were used to determine the osmotically unresponsive solvent volume per unit dry mass of protein. A model is presented that accounts for the osmotic pressure of globular proteins based on a surface-associated osmotically unresponsive solvent volume. The model also accounts for changes in the osmotically unresponsive solvent volume owing to changes in pH, cosolute salt concentration, protein conformation, and… CONTINUE READING

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