A model selection framework to quantify microvascular liver function in gadoxetate‐enhanced MRI: Application to healthy liver, diseased tissue, and hepatocellular carcinoma

@article{Berks2021AMS,
  title={A model selection framework to quantify microvascular liver function in gadoxetate‐enhanced MRI: Application to healthy liver, diseased tissue, and hepatocellular carcinoma},
  author={Michael Berks and R. A Little and Yvonne Watson and Susan Cheung and Anubhav Datta and J. P. B. O'Connor and Davide Scaramuzza and Geoffrey J. M. Parker},
  journal={Magnetic Resonance in Medicine},
  year={2021},
  volume={86},
  pages={1829 - 1844}
}
We introduce a novel, generalized tracer kinetic model selection framework to quantify microvascular characteristics of liver and tumor tissue in gadoxetate‐enhanced dynamic contrast‐enhanced MRI (DCE‐MRI). 
Madym: A C++ toolkit for quantitative DCE-MRI analysis
TLDR
Quantitative DCE- MRI (DCE-MRI), in which one or more tracer-kinetic models are fitted to the contrast-agent concentration time-series, enables the estimation of clinically useful parameters of tissue microvasculature.

References

SHOWING 1-10 OF 44 REFERENCES
DCE‐MRI model selection for investigating disruption of microvascular function in livers with metastatic disease
To evaluate the Akaike information criterion (AIC) model selection technique as a method for detecting differences in microvascular characteristics between tumorous and non‐tumor liver tissue.
Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte‐specific contrast‐enhanced MRI
To assess the feasibility to use dynamic hepatocyte‐specific contrast‐enhanced MRI (DHCE‐MRI) as an imaging‐based liver function test, and to compare two methods for deconvolutional analysis (DA) in
Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast‐enhanced MRI alone and in combination: Preliminary experience
TLDR
Preliminary experience with the use of intravoxel incoherent motion diffusion‐weighted magnetic resonance imaging and dynamic contrast‐enhanced MRI alone and in combination for the diagnosis of liver cirrhosis is reported.
Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease.
TLDR
Initial results in patients with chronic liver diseases show that simultaneous quantification of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI.
Dynamic contrast‐enhanced MRI of neuroendocrine hepatic metastases: A feasibility study using a dual‐input two‐compartment model
TLDR
Initial results indicate that hepatic blood flow and the ratio of fractional vascular volume to fractional interstitial volume may potentially distinguish between the patterns of neuroendocrine hepatic metastases.
Quantitative free-breathing dynamic contrast-enhanced MRI in hepatocellular carcinoma using gadoxetic acid: correlations with Ki67 proliferation status, histological grades, and microvascular density
TLDR
The DCE-MRI derived parameters demonstrated weak but significant correlations with tumor proliferation status, histological grades or microvascular density, respectively, which offers a potential avenue toward non-invasive evaluation of HCC malignancy.
Hepatic metastases: in vivo assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics model.
TLDR
Perfusion parameter maps and region-of-interest analysis revealed that tracer behavior in hepatic metastases-in contrast to that in surrounding normal liver tissue, which effectively involves one compartment-can be described by using two compartments.
Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging
TLDR
The results highlight that dynamic contrast-enhanced MRI with gadoxetate can provide novel quantitative insights into liver function and may therefore prove useful in studies that aim to monitor liver pathology, as well as being an alternative approach for studying hepatic drug-drug interactions.
Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI.
TLDR
Dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) has a potential role as an imaging-based liver function test because the high spatial resolution of MRI enables hepatic function to be assessed on segmental and sub-segmental levels.
Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches
TLDR
Definite cut-off values to determine disease or therapeutic response will help to increase the objectivity and reliability of liver MRI in future, especially in the oncological setting where modern therapies cannot be assessed based on changes in size only.
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