A model selection framework to quantify microvascular liver function in gadoxetate‐enhanced MRI: Application to healthy liver, diseased tissue, and hepatocellular carcinoma

  title={A model selection framework to quantify microvascular liver function in gadoxetate‐enhanced MRI: Application to healthy liver, diseased tissue, and hepatocellular carcinoma},
  author={Michael Berks and R. A Little and Yvonne Watson and Susan Cheung and Anubhav Datta and James P. B. O’Connor and Davide Scaramuzza and Geoffrey J. M. Parker},
  journal={Magnetic Resonance in Medicine},
  pages={1829 - 1844}
We introduce a novel, generalized tracer kinetic model selection framework to quantify microvascular characteristics of liver and tumor tissue in gadoxetate‐enhanced dynamic contrast‐enhanced MRI (DCE‐MRI). 

Madym: A C++ toolkit for quantitative DCE-MRI analysis

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DCE‐MRI model selection for investigating disruption of microvascular function in livers with metastatic disease

To evaluate the Akaike information criterion (AIC) model selection technique as a method for detecting differences in microvascular characteristics between tumorous and non‐tumor liver tissue.

Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte‐specific contrast‐enhanced MRI

To assess the feasibility to use dynamic hepatocyte‐specific contrast‐enhanced MRI (DHCE‐MRI) as an imaging‐based liver function test, and to compare two methods for deconvolutional analysis (DA) in

Prediction of microvascular invasion of hepatocellular carcinoma: Usefulness of peritumoral hypointensity seen on gadoxetate disodium‐enhanced hepatobiliary phase images

To determine whether peritumoral hypointensity seen on hepatobiliary phase images of preoperative gadoxetate disodium‐enhanced magnetic resonance imaging (EOB‐MRI) is useful for predicting

Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast‐enhanced MRI alone and in combination: Preliminary experience

Preliminary experience with the use of intravoxel incoherent motion diffusion‐weighted magnetic resonance imaging and dynamic contrast‐enhanced MRI alone and in combination for the diagnosis of liver cirrhosis is reported.

Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease.

Initial results in patients with chronic liver diseases show that simultaneous quantification of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI.

Dynamic contrast‐enhanced MRI of neuroendocrine hepatic metastases: A feasibility study using a dual‐input two‐compartment model

Initial results indicate that hepatic blood flow and the ratio of fractional vascular volume to fractional interstitial volume may potentially distinguish between the patterns of neuroendocrine hepatic metastases.

Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging.

The analysis of dynamic gadoxetic acid-enhanced MR images with the dual-inlet two-compartment uptake model presents a new and practical approach for measuring arterial and venous perfusion and hepatic function in a single acquisition.

Quantitative free-breathing dynamic contrast-enhanced MRI in hepatocellular carcinoma using gadoxetic acid: correlations with Ki67 proliferation status, histological grades, and microvascular density

The DCE-MRI derived parameters demonstrated weak but significant correlations with tumor proliferation status, histological grades or microvascular density, respectively, which offers a potential avenue toward non-invasive evaluation of HCC malignancy.

Hepatic metastases: in vivo assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics model.

Perfusion parameter maps and region-of-interest analysis revealed that tracer behavior in hepatic metastases-in contrast to that in surrounding normal liver tissue, which effectively involves one compartment-can be described by using two compartments.

Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging

The results highlight that dynamic contrast-enhanced MRI with gadoxetate can provide novel quantitative insights into liver function and may therefore prove useful in studies that aim to monitor liver pathology, as well as being an alternative approach for studying hepatic drug-drug interactions.