A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases.

  • M. Dlakic
  • Published 2002 in
    Protein science : a publication of the Protein…


The replication fork blocks are common in both prokaryotes and eukaryotes. In most cases, these blocks are associated with increased levels of mitotic recombination. One of the best-characterized replication fork blocks in eukaryotes is found in ribosomal DNA (rDNA) repeats of Saccharomyces cerevisiae. It has been shown that the replication fork blocking… (More)


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